HitPredict

Interactor 1: DOCK8 (Q8NF50)
Dedicator of cytokinesis protein 8
Gene: DOCK8

Interactor 2: DOCK6 (Q96HP0)
Dedicator of cytokinesis protein 6
Gene: DOCK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 24255178
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_A~DHR-2_Lobe_A, DHR-2_Lobe_A~DHR-2_Lobe_B, DHR-2_Lobe_B~DHR-2_Lobe_C, DHR-2_Lobe_C~DHR-2_Lobe_C, DOCK-C2~DOCK-C2
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2099 Hs			1 2047
+	Hs
		1244073 DOCK8_HUMAN (1-2099): 0: 2775: 100.00		DOCK7_HUMAN (4-2047): 0: 2404: 64.55
+	Hs
		1244062 DOCK8_HUMAN (1-2099): 0: 2775: 100.00		DOCK8_HUMAN (1-2046): 0: 2393: 51.47
+	Hs
		1293664 DOCK7_HUMAN (7-2092): 0: 2471: 55.37		DOCK6_HUMAN (1-2047): 0: 2516: 100.00
+	At
		1248262 SPK1_ARATH (96-889): 0: 673: 19.81		SPK1_ARATH (88-2027): 0: 1487: 20.95
+	Hs
		1050492 DOCK9_HUMAN (5-177): 2.21e-40: 167: 19.89		DOCK1_HUMAN (299-908): 1.29e-113: 404: 17.00
+	Hs
		1050474 DOCK1_HUMAN (560-867): 5.67e-28: 126: 19.33		DOCK1_HUMAN (299-908): 1.29e-113: 404: 17.00
+	Hs
		1224218 DOCK4_HUMAN (560-867): 5.36e-62: 238: 20.43		DOCK3_HUMAN (298-908): 8.52e-78: 289: 17.24
+	Hs
		1050494 DOCK1_HUMAN (560-867): 5.67e-28: 126: 19.33		DOCK5_HUMAN (299-908): 7.31e-73: 273: 15.42
+	Hs
		1127530 DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50		DOCK9_HUMAN (2-275): 4.4e-46: 185: 20.07
+	Hs
		1286016 DOCK9_HUMAN (5-177): 2.21e-40: 167: 19.89		DOC10_HUMAN (1-164): 3.71e-38: 160: 25.73
+	Hs
		108781 DOC11_HUMAN (22-177): 2.25e-43: 176: 22.50		H0Y572_HUMAN (1279-1405): 8.28e-30: 117: 20.47