HitPredict

Interactor 1: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32265276
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 151
+	Hs
		1242076 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849373 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919790 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1242075 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1242072 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1242074 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		1245518 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849375 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919793 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895853 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1245511 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1245509 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851850 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1243628 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849374 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919791 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895850 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Ce
		1280087 Q9N4I6_CAEEL (120-242): 8.69e-68: 208: 53.66		UBC13_CAEEL (1-150): 2.17e-62: 190: 28.48