HitPredict

Interactor 1: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32265276
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 201
+	Hs
		1242075 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E2_HUMAN (1-201): 6.02e-94: 274: 100.00
+	Hs
		1242072 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		1242076 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919790 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849373 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		1245509 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		1245518 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		896495 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		919793 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849375 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851850 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895853 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		1243628 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919791 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849374 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		895850 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		896498 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		896497 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27