HitPredict

Interactor 1: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Interactor 2: AKTIP (Q9H8T0)
AKT-interacting protein (Ft1) (Fused toes protein homolog)
Gene: AKTIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32265276
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 292
+	Hs
		1242072 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E3_HUMAN (10-222): 2.23e-71: 220: 16.36
+	Hs
		1242076 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D4_HUMAN (74-222): 2.02e-71: 218: 19.33
+	Hs
		919790 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D2_HUMAN (74-222): 2.62e-71: 218: 19.33
+	Hs
		849373 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D1_HUMAN (74-222): 8.21e-70: 214: 18.67
+	Hs
		895849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2D3_HUMAN (74-222): 1.08e-69: 214: 19.33
+	Hs
		1242075 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E2_HUMAN (10-222): 3.68e-68: 212: 14.95
+	Hs
		851849 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UB2E1_HUMAN (46-222): 3.32e-66: 206: 15.73
+	Hs
		1245509 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E3_HUMAN (10-222): 2.23e-71: 220: 16.36
+	Hs
		896495 ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32		UBE2N_HUMAN (77-222): 8.9e-60: 189: 19.05
+	Hs
		1245518 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D4_HUMAN (74-222): 2.02e-71: 218: 19.33
+	Hs
		919793 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D2_HUMAN (74-222): 2.62e-71: 218: 19.33
+	Hs
		849375 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D1_HUMAN (74-222): 8.21e-70: 214: 18.67
+	Hs
		895853 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2D3_HUMAN (74-222): 1.08e-69: 214: 19.33
+	Hs
		1245511 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E2_HUMAN (10-222): 3.68e-68: 212: 14.95
+	Hs
		851850 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UB2E1_HUMAN (46-222): 3.32e-66: 206: 15.73
+	Hs
		919791 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D2_HUMAN (74-222): 2.62e-71: 218: 19.33
+	Hs
		849374 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D1_HUMAN (74-222): 8.21e-70: 214: 18.67
+	Hs
		895850 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UB2D3_HUMAN (74-222): 1.08e-69: 214: 19.33
+	Hs
		896498 ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00		UBE2N_HUMAN (77-222): 8.9e-60: 189: 19.05
+	Hs
		896497 Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86		UBE2N_HUMAN (77-222): 8.9e-60: 189: 19.05