HitPredict

Interactor 1: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Interactor 2: TRIB2 (Q92519)
Tribbles homolog 2 (TRB-2)
Gene: TRIB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	34646775, 25311538, 28514442, 33961781, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 731 Hs			1 343
+	Hs
		1246150 COP1_HUMAN (1-731): 0: 540: 100.00		TRIB1_HUMAN (61-342): 3.68e-131: 380: 66.55
+	Mm
		1225293 COP1_MOUSE (1-731): 3.36e-168: 503: 96.86		TRIB2_MOUSE (1-343): 9.76e-130: 375: 98.25
+	Mm
		1225294 COP1_MOUSE (1-731): 3.36e-168: 503: 96.86		TRIB1_MOUSE (59-342): 2.59e-128: 373: 64.69
+	Hs
		1246149 COP1_HUMAN (1-731): 0: 540: 100.00		TRIB3_HUMAN (47-311): 6.9e-94: 285: 52.45
+	Mm
		1225292 COP1_MOUSE (1-731): 3.36e-168: 503: 96.86		TRIB3_MOUSE (61-331): 1.33e-100: 302: 55.35
+	Hs
		681967 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		AKT1_HUMAN (9-342): 2.12e-135: 395: 20.63
+	Zm
		42668 A0A1D6P5H9_MAIZE (587-730): 2.58e-29: 121: 21.09		A0A1D6PKT0_MAIZE (48-337): 2.99e-110: 330: 25.63
+	Hs
		1083416 RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34		KS6B2_HUMAN (18-342): 2.01e-127: 375: 20.99
+	Sp
		140402 TAF5_SCHPO (336-487): 1.35e-11: 69.8: 10.06		GAD8_SCHPO (49-343): 6.64e-127: 376: 18.89