HitPredict

Interactor 1: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~WD40, UQ_con~zf-C3HC4_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 731 Hs			1 201
+	Hs
		919794 COP1_HUMAN (1-731): 0: 540: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849377 COP1_HUMAN (1-731): 0: 540: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851851 COP1_HUMAN (1-731): 0: 540: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895854 COP1_HUMAN (1-731): 0: 540: 100.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		896507 FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		1163056 TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919755 TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849344 TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	At
		794493 COP1_ARATH (512-730): 3.95e-30: 128: 17.67		COP10_ARATH (43-200): 9e-62: 191: 55.98
+	Hs
		828991 RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49		UBE2A_HUMAN (54-198): 1.67e-70: 212: 35.86