HitPredict

Interactor 1: TR11B (O00300)
Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin)
Gene: TNFRSF11B

Interactor 2: TNF11 (O14788)
Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Gene: TNFSF11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	9520411, 22664871
Identification Methods	pull down, x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	TNF~TNFR_c6
Common GO terms	GO:0005125 - cytokine activity GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 401 Hs			1 317
+	Mm
		139718 TR11B_MOUSE (1-401): 1.87e-156: 448: 85.04		TNF11_MOUSE (1-317): 4.53e-144: 410: 82.70
+	Hs
		155704 TNR11_HUMAN (13-198): 1.37e-43: 162: 28.57		TNF11_HUMAN (1-317): 1.2e-151: 429: 100.00
+	Mm
		192442 TNR11_MOUSE (5-195): 1.44e-47: 173: 30.93		TNF11_MOUSE (1-317): 4.53e-144: 410: 82.70
+	Hs
		639551 TNR5_HUMAN (7-190): 3.61e-46: 161: 29.79		CD40L_HUMAN (32-313): 4.6e-79: 243: 21.45
+	Hs
		305092 TNF6B_HUMAN (23-277): 4.53e-49: 170: 31.78		TNF15_HUMAN (119-313): 3.14e-65: 207: 22.55
+	Hs
		352486 TNR1B_HUMAN (4-231): 8.43e-51: 178: 29.66		TNFA_HUMAN (130-313): 1.02e-56: 185: 20.41
+	Hs
		313618 TNF6B_HUMAN (23-277): 4.53e-49: 170: 31.78		TNFL6_HUMAN (127-313): 3.4e-56: 185: 23.68
+	Hs
		207212 TNF6B_HUMAN (23-277): 4.53e-49: 170: 31.78		TNF14_HUMAN (144-313): 2.87e-56: 184: 25.86
+	Mm
		420391 TNR1B_MOUSE (4-237): 4.58e-48: 171: 28.98		TNFA_MOUSE (130-313): 7.67e-56: 182: 22.28
+	Hs
		352517 TNR3_HUMAN (3-195): 5.18e-46: 165: 24.52		TNFA_HUMAN (130-313): 1.02e-56: 185: 20.41
+	Hs
		207225 TNR3_HUMAN (3-195): 5.18e-46: 165: 24.52		TNF14_HUMAN (144-313): 2.87e-56: 184: 25.86
+	Mm
		632460 TNR6_MOUSE (15-278): 5.56e-42: 151: 18.38		TNFL6_MOUSE (127-313): 2.59e-57: 188: 23.16
+	Hs
		352497 TNR6_HUMAN (31-277): 3.82e-42: 152: 22.57		TNFA_HUMAN (130-313): 1.02e-56: 185: 20.41
+	Rn
		561443 TNR1B_RAT (4-238): 2.34e-43: 159: 27.64		TNFA_RAT (130-313): 3.48e-54: 178: 21.29
+	Hs
		632214 TNR6_HUMAN (31-277): 3.82e-42: 152: 22.57		TNFL6_HUMAN (127-313): 3.4e-56: 185: 23.68
+	Mm
		1174754 Q71F55_MOUSE (2-189): 3.55e-40: 145: 29.23		TNF14_MOUSE (144-313): 2.09e-57: 186: 28.16
+	Mm
		838554 TNR3_MOUSE (17-192): 3.27e-38: 144: 25.40		TNF14_MOUSE (144-313): 2.09e-57: 186: 28.16
+	Hs
		738657 TNR3_HUMAN (3-195): 5.18e-46: 165: 24.52		TNFC_HUMAN (134-313): 1.26e-48: 164: 20.31
+	Hs
		352409 TNR1B_HUMAN (4-231): 8.43e-51: 178: 29.66		TNFB_HUMAN (160-313): 4.8e-43: 148: 23.87
+	Hs
		352410 TNR3_HUMAN (3-195): 5.18e-46: 165: 24.52		TNFB_HUMAN (160-313): 4.8e-43: 148: 23.87