HitPredict

Interactor 1: SH3K1 (Q8R550)
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
Gene: Sh3kbp1

Interactor 2: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21725061
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Mm			1 1191
+	Hs
		1271562 SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		1271571 CD2AP_HUMAN (1-708): 1.38e-92: 303: 31.06		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		176485 SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		176509 CD2AP_HUMAN (1-708): 1.38e-92: 303: 31.06		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Hs
		557759 NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		166055 SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		166060 CD2AP_HUMAN (1-708): 1.38e-92: 303: 31.06		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		176448 ITSN1_HUMAN (205-465): 2.83e-17: 88.6: 15.81		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Mm
		1159873 ITSN1_MOUSE (1-131): 1.6e-16: 86.3: 24.43		SHIP2_MOUSE (5-1109): 0: 675: 38.98
+	Hs
		166030 NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Dm
		112574 M9ND00_DROME (273-580): 6.44e-25: 113: 14.58		Q5U0V7_DROME (257-1046): 3.97e-158: 506: 16.71
+	Hs
		166049 ITSN1_HUMAN (205-465): 2.83e-17: 88.6: 15.81		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		166056 ITSN2_HUMAN (247-409): 9.74e-17: 87.1: 19.02		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		1136550 SPD2A_HUMAN (3-696): 3.46e-49: 188: 15.01		INP5E_HUMAN (193-759): 4.15e-100: 333: 20.31
+	Hs
		203241 SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62
+	Hs
		243127 NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		203208 NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62
+	Hs
		203230 SH319_HUMAN (5-373): 3.57e-22: 103: 17.34		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62
+	Hs
		243142 ARHG6_HUMAN (262-383): 2.93e-15: 81.7: 23.62		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		203228 ITSN1_HUMAN (205-465): 2.83e-17: 88.6: 15.81		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62