HitPredict

Interactor 1: Q8R5B8 (Q8R5B8)
Crkl protein
Gene: Crkl

Interactor 2: GAB1 (Q9QYY0)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	10871282
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 98 Mm			1 695
+	Hs
		802837 CRKL_HUMAN (1-98): 1.58e-37: 129: 97.96		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Mm
		1141170 GRB2_MOUSE (2-96): 8.48e-35: 119: 23.96		GAB1_MOUSE (1-695): 2.76e-116: 366: 100.00
+	Hs
		433345 YES_HUMAN (4-92): 1.11e-32: 120: 34.02		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		924547 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		522965 SRC_HUMAN (4-92): 4.3e-32: 118: 36.08		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		802920 CRKL_HUMAN (1-98): 1.58e-37: 129: 97.96		GAB2_HUMAN (3-692): 1.8e-86: 287: 37.09
+	Hs
		924959 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		GAB2_HUMAN (3-692): 1.8e-86: 287: 37.09
+	Hs
		523213 SRC_HUMAN (4-92): 4.3e-32: 118: 36.08		GAB2_HUMAN (3-692): 1.8e-86: 287: 37.09
+	Mm
		1114082 GRB2_MOUSE (2-96): 8.48e-35: 119: 23.96		Q3ZB59_MOUSE (3-692): 1.55e-74: 255: 36.53
+	Mm
		1141175 GRB2_MOUSE (2-96): 8.48e-35: 119: 23.96		GAB2_MOUSE (3-692): 2.13e-74: 254: 36.53
+	Mm
		69824 B1AT92_MOUSE (2-96): 6.43e-35: 119: 23.96		GAB2_MOUSE (3-692): 2.13e-74: 254: 36.53
+	Hs
		924730 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		GAB3_HUMAN (1-684): 2.99e-53: 195: 26.19
+	Hs
		523086 SRC_HUMAN (4-92): 4.3e-32: 118: 36.08		GAB3_HUMAN (1-684): 2.99e-53: 195: 26.19
+	Dm
		993221 GRAP_DROME (1-96): 4.21e-34: 117: 26.04		DOS_DROME (8-664): 2.14e-44: 173: 15.40
+	Hs
		924876 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		PKHA2_HUMAN (2-225): 2.12e-34: 138: 20.00
+	Hs
		802907 CRKL_HUMAN (1-98): 1.58e-37: 129: 97.96		PKHA1_HUMAN (6-155): 3.11e-26: 113: 25.49
+	Hs
		554292 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		MUC1_HUMAN (176-682): 2.08e-20: 98.8: 10.65
+	Hs
		522749 SRC_HUMAN (4-92): 4.3e-32: 118: 36.08		MUC1_HUMAN (176-682): 2.08e-20: 98.8: 10.65
+	Hs
		203218 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		SYNJ1_HUMAN (125-576): 2.41e-18: 92.2: 12.29
+	Hs
		924760 GRB2_HUMAN (2-96): 8.86e-35: 119: 23.96		PRG4_HUMAN (97-666): 8.37e-12: 71: 8.58