HitPredict

Interactor 1: SPK1 (Q8SAB7)
Guanine nucleotide exchange factor SPIKE 1
Gene: SPK1

Interactor 2: RAC9 (Q9XGU0)
Rac-like GTP-binding protein ARAC9 (GTPase protein ROP8)
Gene: ARAC9

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	17267444
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0007264 - small GTPase-mediated signal transduction GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1830 At			1 209
+	At
		1105166 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC5_ARATH (14-190): 9.4e-80: 238: 79.66
+	At
		287603 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC10_ARATH (11-192): 1.76e-79: 238: 70.33
+	At
		1105136 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC4_ARATH (15-190): 1.93e-79: 237: 80.68
+	At
		1105105 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC1_ARATH (14-209): 1.73e-75: 227: 74.49
+	At
		1248267 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC6_ARATH (14-209): 1.7e-74: 225: 74.49
+	At
		1248268 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC8_ARATH (11-192): 8.17e-73: 220: 71.98
+	Hs
		925332 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Hs
		892410 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC3_HUMAN (19-190): 7.09e-75: 225: 60.92
+	Hs
		545421 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC2_HUMAN (19-209): 3.71e-74: 223: 55.96
+	Hs
		925588 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Hs
		892573 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC3_HUMAN (19-190): 7.09e-75: 225: 60.92
+	Hs
		951301 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RHOG_HUMAN (19-209): 8.91e-75: 225: 53.89
+	Hs
		545596 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC2_HUMAN (19-209): 3.71e-74: 223: 55.96
+	Hs
		925518 DOCK6_HUMAN (16-979): 0: 755: 20.07		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Hs
		925526 DOCK7_HUMAN (14-731): 0: 656: 21.52		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Hs
		925448 DOCK8_HUMAN (14-731): 0: 602: 20.24		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Hs
		925429 DOCK4_HUMAN (463-1026): 7.18e-139: 479: 16.22		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Dm
		776892 Q8MQW7_DROME (1270-1830): 2.47e-131: 446: 15.17		RAC1_DROME (19-209): 2.35e-74: 224: 56.48
+	Hs
		925425 DOCK3_HUMAN (463-1026): 4.99e-70: 264: 15.18		RAC1_HUMAN (19-209): 3.33e-77: 231: 58.03
+	Mm
		925807 DOCK1_MOUSE (463-1017): 1.06e-47: 190: 15.15		RAC1_MOUSE (19-209): 3.33e-77: 231: 58.03