HitPredict

Interactor 1: Q8SXB1 (Q8SXB1)
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a)
Gene: Vps2

Interactor 2: Q9Y162 (Q9Y162)
BcDNA.GH02678 (Vacuolar protein sorting 4, isoform A (EC 3.6.1.3)) (Vacuolar protein sorting 4, isoform B)
Gene: Vps4

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016197 - endosomal transport GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Dm			1 442
+	Dm
		1362012 Q9VBI3_DROME (1-243): 7.95e-50: 165: 100.00		Q9Y162_DROME (1-442): 6.4e-129: 381: 100.00
+	Hs
		260164 CHM2B_HUMAN (1-200): 1.12e-46: 156: 33.00		VPS4B_HUMAN (2-442): 5.26e-128: 379: 74.21
+	Hs
		1357378 CHM2B_HUMAN (1-200): 1.12e-46: 156: 33.00		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Hs
		208804 CHM2A_HUMAN (1-178): 9.35e-45: 151: 79.21		VPS4B_HUMAN (2-442): 5.26e-128: 379: 74.21
+	Mm
		804060 CHM2A_MOUSE (1-186): 2.34e-44: 150: 76.88		VPS4B_MOUSE (2-442): 7.61e-128: 378: 75.34
+	Hs
		208869 CHM2A_HUMAN (1-178): 9.35e-45: 151: 79.21		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Dm
		1371193 Q9VN02_DROME (2-195): 2.51e-41: 142: 22.17		Q9Y162_DROME (1-442): 6.4e-129: 381: 100.00
+	Dm
		1373132 Q9VRJ5_DROME (3-186): 5.72e-41: 141: 34.24		Q9Y162_DROME (1-442): 6.4e-129: 381: 100.00
+	Hs
		1357379 CHMP3_HUMAN (1-181): 5.51e-43: 146: 22.10		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Dm
		1279493 Q95SH2_DROME (2-201): 5.46e-40: 138: 27.00		Q9Y162_DROME (1-442): 6.4e-129: 381: 100.00
+	Hs
		260145 CHM1B_HUMAN (2-191): 1.72e-38: 134: 26.84		VPS4B_HUMAN (2-442): 5.26e-128: 379: 74.21
+	Hs
		260156 CHM1A_HUMAN (2-198): 9.05e-39: 134: 19.29		VPS4B_HUMAN (2-442): 5.26e-128: 379: 74.21
+	Hs
		1185556 CHM1B_HUMAN (2-191): 1.72e-38: 134: 26.84		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Hs
		1336687 CHM1A_HUMAN (2-198): 9.05e-39: 134: 19.29		VPS4A_HUMAN (7-441): 3.49e-126: 374: 73.79
+	Sc
		732854 DID4_YEAST (2-243): 1.76e-48: 161: 39.10		VPS4_YEAST (1-442): 1.8e-112: 339: 57.66
+	Hs
		208865 CHM2A_HUMAN (1-178): 9.35e-45: 151: 79.21		SPAST_HUMAN (62-440): 1.51e-113: 348: 36.84
+	At
		1352475 VPS2A_ARATH (1-242): 1.14e-50: 166: 47.52		VPS4_ARATH (4-442): 9.6e-106: 322: 52.02
+	Hs
		1185555 CHM1B_HUMAN (2-191): 1.72e-38: 134: 26.84		SPAST_HUMAN (62-440): 1.51e-113: 348: 36.84
+	At
		1013169 VPS2B_ARATH (2-177): 4.97e-41: 141: 36.93		VPS4_ARATH (4-442): 9.6e-106: 322: 52.02
+	At
		1352776 CHM1B_ARATH (2-202): 5.22e-41: 141: 21.39		VPS4_ARATH (4-442): 9.6e-106: 322: 52.02