HitPredict

Interactor 1: CHM4 (Q8T0Q4)
Charged multivesicular body protein 4 (CHMP4) (ESCRT-III complex core component shrb) (Protein Shrub)
Gene: shrb

Interactor 2: Q9VBI3 (Q9VBI3)
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a)
Gene: Vps2

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Dm			1 256
+	Ce
		1090380 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9U2F6_CAEEL (1-256): 7.98e-48: 160: 63.28
+	Dm
		1249820 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VRJ5_DROME (2-213): 4.73e-39: 136: 32.08
+	Ce
		1090378 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9GYK4_CAEEL (4-212): 1.63e-37: 132: 28.23
+	Dm
		1249812 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q95SH2_DROME (14-215): 9.48e-35: 125: 26.73
+	Dm
		1249819 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		Q9VN02_DROME (4-208): 1.49e-34: 125: 23.19
+	Dm
		1249822 CHM4_DROME (1-226): 7.65e-50: 163: 100.00		CHMP5_DROME (1-206): 1.51e-33: 123: 18.31
+	Hs
		92838 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		E9PSI1_HUMAN (1-195): 3e-40: 149: 16.04
+	At
		1013158 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VPS2B_ARATH (3-213): 1.29e-38: 136: 31.82
+	Hs
		208860 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM2A_HUMAN (1-190): 1.75e-41: 143: 77.90
+	Ce
		1090379 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		Q9TXI3_CAEEL (14-208): 1.84e-32: 119: 23.47
+	Hs
		1330562 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM2B_HUMAN (7-212): 4.34e-40: 139: 33.50
+	At
		1013164 VPS2A_ARATH (3-219): 2.44e-38: 134: 16.97		VPS2B_ARATH (3-213): 1.29e-38: 136: 31.82
+	Ce
		183904 Q18886_CAEEL (1-226): 7.27e-48: 158: 55.51		O16458_CAEEL (1-202): 1.3e-29: 112: 17.70
+	Hs
		1330574 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHMP3_HUMAN (4-194): 9.48e-38: 133: 23.83
+	Hs
		1330527 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHMP5_HUMAN (1-203): 1.85e-36: 130: 19.05
+	At
		98407 F4JXR3_ARATH (4-217): 1.56e-41: 144: 17.05		VP241_ARATH (3-209): 5.16e-33: 121: 25.12
+	At
		1322582 VP601_ARATH (4-217): 2.12e-41: 142: 19.91		VP241_ARATH (3-209): 5.16e-33: 121: 25.12
+	Zm
		77175 B4FU00_MAIZE (4-213): 9.73e-40: 137: 20.74		B4FU00_MAIZE (1-229): 8.21e-34: 123: 17.72
+	Hs
		1330513 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM1A_HUMAN (15-212): 6.81e-32: 117: 19.19
+	Hs
		1185549 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		CHM1B_HUMAN (15-208): 6.34e-31: 115: 26.29