HitPredict

Interactor 1: CHM4 (Q8T0Q4)
Charged multivesicular body protein 4 (CHMP4) (ESCRT-III complex core component shrb) (Protein Shrub)
Gene: shrb

Interactor 2: C2D1 (Q9VKJ9)
Coiled-coil and C2 domain-containing protein 1-like (Lethal (2) giant discs 1 protein)
Gene: l(2)gd1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	22389409, 28564595
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000281 - mitotic cytokinesis GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0048132 - female germ-line stem cell asymmetric division
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 226 Dm			1 816
+	Hs
		1132384 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		C2D1B_HUMAN (4-815): 2.81e-156: 479: 30.89
+	Hs
		1158636 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		C2D1A_HUMAN (1-815): 3.66e-148: 461: 30.38
+	Hs
		1158648 CHM4B_HUMAN (1-225): 9.83e-39: 135: 56.96		C2D1A_HUMAN (1-815): 3.66e-148: 461: 30.38
+	Hs
		1158643 CHM4A_HUMAN (1-226): 7.48e-37: 130: 52.38		C2D1A_HUMAN (1-815): 3.66e-148: 461: 30.38
+	Hs
		1264782 CHM4C_HUMAN (1-226): 4.9e-42: 144: 48.50		TITIN_HUMAN (101-498): 5.31e-09: 62.3: 9.70