HitPredict

Interactor 1: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Interactor 2: DEFI8 (Q9VTT9)
Differentially expressed in FDCP 8 homolog
Gene: DEF8

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.80	0.587

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Pkinase
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 669 Dm			1 492
+	Hs
		981048 KPCT_HUMAN (2-354): 2.28e-130: 402: 20.83		KPCD_HUMAN (49-282): 8.01e-58: 204: 13.59
+	Hs
		681803 AKT1_HUMAN (13-360): 6.81e-132: 398: 20.06		KPCD_HUMAN (49-282): 8.01e-58: 204: 13.59
+	Hs
		647878 MARK3_HUMAN (11-664): 2.35e-136: 419: 15.26		KPCT_HUMAN (70-282): 3.39e-48: 178: 14.63
+	Hs
		129013 PLK4_HUMAN (40-641): 1.11e-128: 405: 19.44		MRCKA_HUMAN (49-378): 3.18e-51: 190: 14.29
+	Hs
		969093 MARK2_HUMAN (3-614): 2.18e-132: 410: 15.72		KPCE_HUMAN (119-301): 1.32e-48: 180: 18.69
+	Hs
		623873 KPCL_HUMAN (5-362): 3.95e-131: 403: 20.49		KPCE_HUMAN (119-301): 1.32e-48: 180: 18.69
+	Mm
		554867 AKT1_MOUSE (13-360): 1.14e-132: 400: 20.33		KPCE_MOUSE (119-301): 8.15e-49: 180: 18.69
+	Hs
		981046 KPCT_HUMAN (2-354): 2.28e-130: 402: 20.83		KPCT_HUMAN (70-282): 3.39e-48: 178: 14.63
+	Hs
		681799 AKT1_HUMAN (13-360): 6.81e-132: 398: 20.06		KPCT_HUMAN (70-282): 3.39e-48: 178: 14.63
+	Hs
		566289 KPCL_HUMAN (5-362): 3.95e-131: 403: 20.49		KPCA_HUMAN (165-214): 3.34e-16: 83.4: 22.00
+	Hs
		408561 AKT1_HUMAN (13-360): 6.81e-132: 398: 20.06		KPCB_HUMAN (165-233): 4.05e-17: 86.5: 17.39
+	Hs
		981056 KPCT_HUMAN (2-354): 2.28e-130: 402: 20.83		GRP3_HUMAN (131-214): 5.31e-10: 64: 23.81
+	Hs
		568728 KAPCA_HUMAN (6-346): 3.17e-130: 389: 21.94		GRP3_HUMAN (131-214): 5.31e-10: 64: 23.81
+	Hs
		981057 M4K3_HUMAN (38-308): 1.71e-71: 250: 44.25		KPCT_HUMAN (70-282): 3.39e-48: 178: 14.63
+	Mm
		969035 M4K3_MOUSE (38-308): 1.05e-70: 248: 43.89		KPCT_MOUSE (70-282): 1.54e-48: 179: 14.63
+	Mm
		934621 TNIK_MOUSE (33-320): 1.02e-62: 228: 41.06		KPCB_MOUSE (165-233): 3.61e-17: 86.5: 17.39
+	Mm
		930562 TNIK_MOUSE (33-320): 1.02e-62: 228: 41.06		KPCG_MOUSE (161-214): 1.18e-16: 84.9: 29.63