HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.738

Property	Details
Experiments	26701932, 25071155, 31048545, 36398662, 31340145, 33961781
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 736
+	Hs
		124995 WWP2_HUMAN (1-870): 0: 982: 100.00		DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32
+	Hs
		151140 ITCH_HUMAN (1-870): 0: 902: 54.26		DVL2_HUMAN (1-736): 0: 547: 100.00
+	Hs
		151182 WWP1_HUMAN (1-870): 0: 888: 58.38		DVL2_HUMAN (1-736): 0: 547: 100.00
+	Hs
		150747 ITCH_HUMAN (1-870): 0: 902: 54.26		DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32
+	Hs
		1273604 ITCH_HUMAN (1-870): 0: 902: 54.26		DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04
+	Hs
		150752 WWP1_HUMAN (1-870): 0: 888: 58.38		DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32
+	Hs
		1273633 WWP1_HUMAN (1-870): 0: 888: 58.38		DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04
+	Hs
		151146 NED4L_HUMAN (5-867): 0: 785: 32.17		DVL2_HUMAN (1-736): 0: 547: 100.00
+	Hs
		150684 NEDD4_HUMAN (90-867): 0: 731: 35.94		DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32
+	Hs
		150725 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32
+	Hs
		1192152 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04
+	Hs
		125592 WWP2_HUMAN (1-870): 0: 982: 100.00		INADL_HUMAN (243-345): 1.2e-12: 73.8: 26.85
+	Hs
		1271021 NED4L_HUMAN (5-867): 0: 785: 32.17		DLG3_HUMAN (80-706): 1.51e-73: 256: 14.93
+	Mm
		1143429 NED4L_MOUSE (4-867): 0: 781: 31.91		DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85
+	Hs
		1246432 WWP1_HUMAN (1-870): 0: 888: 58.38		INADL_HUMAN (243-345): 1.2e-12: 73.8: 26.85
+	Mm
		93273 E9PXB7_MOUSE (151-867): 0: 684: 37.10		DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85
+	Mm
		93267 E9PXB7_MOUSE (151-867): 0: 684: 37.10		DLG3_MOUSE (80-706): 1.04e-71: 252: 15.33
+	Hs
		1021523 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92
+	Hs
		151206 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DVL2_HUMAN (1-736): 0: 547: 100.00
+	Mm
		808344 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		DLG3_MOUSE (80-706): 1.04e-71: 252: 15.33