HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0036211 - protein modification process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 153
+	Hs
		125808 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93
+	Hs
		125262 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93
+	Hs
		125335 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58
+	Hs
		125300 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24
+	Hs
		125655 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E2_HUMAN (3-148): 7.71e-69: 208: 32.65
+	Hs
		125629 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97
+	Hs
		125263 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01
+	Hs
		159084 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00
+	Hs
		125359 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26
+	Mm
		932608 WWP2_MOUSE (1-870): 0: 971: 95.98		UB2L3_MOUSE (1-152): 6.11e-66: 199: 55.26
+	Hs
		1294888 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93
+	Hs
		849411 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93
+	Hs
		919827 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58
+	Hs
		895882 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24
+	Hs
		849444 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93
+	Hs
		1294835 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E2_HUMAN (3-148): 7.71e-69: 208: 32.65
+	Hs
		1282329 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97
+	Hs
		895910 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24
+	Hs
		851871 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01
+	Hs
		932560 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26