HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: LRAD4 (O15165)
Low-density lipoprotein receptor class A domain-containing protein 4
Gene: LDLRAD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	31048545, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 306
+	Hs
		170560 ITCH_HUMAN (1-870): 0: 902: 54.26		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170566 WWP1_HUMAN (1-870): 0: 888: 58.38		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170561 NED4L_HUMAN (5-867): 0: 785: 32.17		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170532 NEDD4_HUMAN (90-867): 0: 731: 35.94		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		1282578 NED4L_HUMAN (5-867): 0: 785: 32.17		PMEPA_HUMAN (57-304): 1.13e-133: 382: 66.14
+	Hs
		808211 NEDD4_HUMAN (90-867): 0: 731: 35.94		PMEPA_HUMAN (57-304): 1.13e-133: 382: 66.14
+	Hs
		170569 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170568 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170573 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Hs
		170549 HECW1_HUMAN (187-523): 3.02e-13: 76.4: 19.58		LRAD4_HUMAN (1-306): 0: 578: 100.00
+	Mm
		57497 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		A2APF4_MOUSE (56-302): 2.79e-124: 358: 64.54
+	Mm
		808374 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		PMEPA_MOUSE (56-302): 1.19e-122: 353: 64.54