HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RPB4 (O15514)
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)
Gene: POLR2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25071155, 31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 142
+	Hs
		181453 WWP1_HUMAN (1-870): 0: 888: 58.38		RPB4_HUMAN (1-142): 4e-59: 181: 100.00
+	Sc
		593086 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RPB4_YEAST (42-140): 3.4e-27: 102: 35.58
+	Sc
		593068 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		RPB4_YEAST (42-140): 3.4e-27: 102: 35.58