HitPredict

Interactor 1: Q8T4A9 (Q8T4A9)
Exosome complex component RRP45 (Exosome component 9)
Gene: Rrp45

Interactor 2: Q9VC93 (Q9VC93)
Dis3, isoform A (EC 3.1.13.-) (Dis3, isoform B)
Gene: Dis3

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	20421210, 19220816
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, RNB~RNase_PH, OB_Dis3~RNase_PH_C
Common GO terms	GO:0000176 - nuclear exosome (RNase complex) GO:0000177 - cytoplasmic exosome (RNase complex) GO:0000178 - exosome (RNase complex)
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Dm			1 982
+	Dm
		1100453 Q29QQ9_DROME (11-291): 1.58e-71: 228: 20.62		Q9VC93_DROME (1-972): 0: 1284: 100.00
+	Dm
		1362696 Q9VK19_DROME (25-290): 5.89e-52: 176: 17.78		Q9VC93_DROME (1-972): 0: 1284: 100.00
+	Dm
		1362699 Q9VW53_DROME (9-327): 1.61e-45: 161: 16.26		Q9VC93_DROME (1-972): 0: 1284: 100.00
+	Hs
		1284999 EXOS8_HUMAN (12-281): 1.09e-85: 264: 24.18		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		986739 EXOS9_HUMAN (9-288): 8.67e-82: 259: 35.71		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		1063785 EXOS7_HUMAN (12-290): 4.86e-80: 250: 26.92		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Hs
		1342631 EXOS4_HUMAN (20-283): 5.67e-54: 181: 18.08		RRP44_HUMAN (1-965): 0: 1174: 54.57
+	Sp
		252320 RRP45_SCHPO (11-294): 2.04e-85: 264: 31.34		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Sc
		984317 RRP45_YEAST (11-286): 2.71e-80: 251: 30.80		RRP44_YEAST (2-946): 0: 992: 41.26
+	Hs
		1257149 EXOS8_HUMAN (12-281): 1.09e-85: 264: 24.18		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Hs
		986702 EXOS9_HUMAN (9-288): 8.67e-82: 259: 35.71		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Sp
		740351 RRP43_SCHPO (8-263): 8.85e-67: 215: 22.52		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Hs
		1063744 EXOS7_HUMAN (12-290): 4.86e-80: 250: 26.92		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	At
		96521 RRP41_ARATH (26-283): 1.22e-54: 182: 20.46		F4INI6_ARATH (1-945): 0: 1030: 41.70
+	Sp
		194782 RRP41_SCHPO (18-281): 7.44e-48: 165: 18.15		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Sp
		223963 RRP42_SCHPO (12-276): 1.23e-42: 153: 18.92		DIS3_SCHPO (3-945): 0: 1016: 42.65
+	Hs
		1257153 EXOS4_HUMAN (20-283): 5.67e-54: 181: 18.08		DI3L1_HUMAN (1-958): 0: 973: 32.08
+	Sc
		809596 RRP41_YEAST (26-287): 1.56e-40: 146: 16.67		RRP44_YEAST (2-946): 0: 992: 41.26
+	Sc
		993688 RRP42_YEAST (11-239): 2.5e-39: 143: 17.99		RRP44_YEAST (2-946): 0: 992: 41.26
+	Pf
		1212338 Q8ID62_PLAF7 (14-345): 1.5e-89: 280: 26.30		Q8IDB6_PLAF7 (4-936): 0: 807: 27.45