HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25266661, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 636
+	Hs
		125430 WWP2_HUMAN (1-870): 0: 982: 100.00		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		516643 ITCH_HUMAN (1-870): 0: 902: 54.26		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		125147 WWP2_HUMAN (1-870): 0: 982: 100.00		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Sc
		376913 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		PABP_YEAST (2-335): 1.06e-64: 225: 26.71
+	Hs
		582364 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		582506 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		1126965 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		PAP1M_HUMAN (294-387): 4.99e-19: 87.4: 24.74