HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SCNNA (P37088)
Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
Gene: SCNN1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12167593
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 669
+	Hs
		739603 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNA_HUMAN (1-669): 0: 729: 100.00
+	Hs
		739608 WWP1_HUMAN (1-870): 0: 888: 58.38		SCNNA_HUMAN (1-669): 0: 729: 100.00
+	Hs
		125257 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNG_HUMAN (36-650): 0: 568: 33.44
+	Hs
		125256 WWP2_HUMAN (1-870): 0: 982: 100.00		SCNNB_HUMAN (54-666): 0: 564: 30.54
+	Hs
		739604 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNA_HUMAN (1-669): 0: 729: 100.00
+	Rn
		739630 Q4V8H7_RAT (1-870): 0: 902: 58.85		SCNNG_RAT (36-650): 0: 568: 32.75
+	Hs
		845977 ITCH_HUMAN (1-870): 0: 902: 54.26		SCNNB_HUMAN (54-666): 0: 564: 30.54
+	Hs
		739582 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNA_HUMAN (1-669): 0: 729: 100.00
+	Hs
		845991 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNG_HUMAN (36-650): 0: 568: 33.44
+	Hs
		845978 NED4L_HUMAN (5-867): 0: 785: 32.17		SCNNB_HUMAN (54-666): 0: 564: 30.54
+	Mm
		93272 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNA_MOUSE (1-665): 0: 661: 82.66
+	Mm
		1208291 NED4L_MOUSE (4-867): 0: 781: 31.91		SCNNB_MOUSE (54-666): 0: 554: 31.06
+	Hs
		739597 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		SCNNA_HUMAN (1-669): 0: 729: 100.00
+	Hs
		808050 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNG_HUMAN (36-650): 0: 568: 33.44
+	Hs
		808049 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNNB_HUMAN (54-666): 0: 564: 30.54
+	Mm
		93286 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNG_MOUSE (36-650): 0: 576: 33.12
+	Mm
		93285 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNNB_MOUSE (54-666): 0: 554: 31.06
+	Rn
		739625 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNA_RAT (1-668): 0: 680: 82.74
+	Rn
		739631 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNG_RAT (36-650): 0: 568: 32.75
+	Rn
		739628 NEDD4_RAT (10-364): 4.8e-54: 204: 19.36		SCNNB_RAT (54-666): 0: 566: 31.22