HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PRC2A (P48634)
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)
Gene: PRRC2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25071155, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 2157
+	Hs
		125509 WWP2_HUMAN (1-870): 0: 982: 100.00		PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60
+	Hs
		125795 WWP2_HUMAN (1-870): 0: 982: 100.00		SRRM2_HUMAN (238-2035): 2.29e-34: 147: 9.83
+	Hs
		125403 WWP2_HUMAN (1-870): 0: 982: 100.00		ZO1_HUMAN (265-982): 3.45e-30: 133: 13.23
+	Hs
		554367 WWP1_HUMAN (1-870): 0: 888: 58.38		MUC1_HUMAN (1123-2148): 1.84e-48: 193: 12.03
+	Hs
		125817 WWP2_HUMAN (1-870): 0: 982: 100.00		PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13
+	Hs
		1294841 ITCH_HUMAN (1-870): 0: 902: 54.26		MINT_HUMAN (338-2157): 4.08e-29: 130: 10.26
+	Hs
		1132692 WWP1_HUMAN (1-870): 0: 888: 58.38		ZEP3_HUMAN (972-2156): 3.02e-13: 78.2: 8.72
+	Hs
		807761 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83
+	Hs
		1192175 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		CIC_HUMAN (8-701): 6.41e-09: 63.9: 8.78
+	Hs
		807849 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83
+	Hs
		1264807 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		TITIN_HUMAN (25-1264): 8.01e-19: 96.8: 11.60
+	Hs
		1350517 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		CABIN_HUMAN (211-1108): 5.1e-10: 67.2: 11.31