HitPredict

Interactor 1: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Interactor 2: TRAF4 (Q9BUZ4)
TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
Gene: TRAF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.653

Property	Details
Experiments	29121065, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 470
+	Hs
		1020823 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		129581 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRAF5_HUMAN (2-465): 7.74e-104: 322: 24.95
+	Hs
		1024716 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRAF3_HUMAN (3-465): 2.47e-92: 292: 22.99
+	Hs
		1020798 LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21		TRAF2_HUMAN (2-465): 4.35e-117: 354: 29.86
+	Hs
		1252569 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		1023731 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		1023721 LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21		TRAF1_HUMAN (16-465): 6.07e-72: 235: 24.18
+	Hs
		585019 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		RO52_HUMAN (9-286): 3.93e-44: 163: 14.84
+	Hs
		1149890 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		TRI68_HUMAN (8-306): 1.43e-40: 153: 16.56
+	Hs
		1252551 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		PZRN3_HUMAN (7-229): 6.29e-39: 152: 19.83
+	Hs
		1232922 LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21		PZRN3_HUMAN (7-229): 6.29e-39: 152: 19.83
+	Hs
		1168358 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		PZRN4_HUMAN (6-112): 6.8e-16: 82.6: 29.91
+	Hs
		1232884 LNX1_HUMAN (1-728): 1.08e-139: 429: 100.00		LNX2_HUMAN (6-140): 3.01e-11: 67.6: 27.74
+	Mm
		1112691 DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40		Q3UHJ1_MOUSE (3-465): 3.57e-116: 353: 26.16
+	Hs
		1168357 LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21		PZRN4_HUMAN (6-112): 6.8e-16: 82.6: 29.91
+	Hs
		1232882 LNX2_HUMAN (3-728): 5.7e-116: 366: 45.21		LNX2_HUMAN (6-140): 3.01e-11: 67.6: 27.74
+	Mm
		1141406 DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40		TRAF3_MOUSE (3-465): 4.11e-101: 315: 24.17
+	Hs
		942403 DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22		TRAF6_HUMAN (3-464): 1.61e-84: 271: 24.79
+	Hs
		280063 MPDZ_HUMAN (513-728): 2.84e-20: 98.6: 18.43		RN166_HUMAN (9-146): 3.64e-16: 79.5: 25.90
+	Hs
		1246419 INADL_HUMAN (261-396): 1.13e-15: 83.6: 21.74		RN166_HUMAN (9-146): 3.64e-16: 79.5: 25.90