HitPredict

Interactor 1: UBA3 (Q8TBC4)
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)
Gene: UBA3

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 463 Hs			1 1024
+	Hs
		1039446 ULA1_HUMAN (48-448): 1.5e-99: 310: 18.16		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1354311 SAE2_HUMAN (57-421): 9.94e-90: 287: 28.75		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1353972 SAE1_HUMAN (44-350): 1.79e-87: 272: 17.38		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		48142 UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		607185 UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		983261 SAE2_HUMAN (57-421): 9.94e-90: 287: 28.75		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		983260 SAE1_HUMAN (44-350): 1.79e-87: 272: 17.38		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		125155 UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		48079 UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		48128 UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		607135 UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22