HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 363
+	Hs
		125282 WWP2_HUMAN (1-870): 0: 982: 100.00		RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03
+	Hs
		125787 WWP2_HUMAN (1-870): 0: 982: 100.00		UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47
+	Hs
		125739 WWP2_HUMAN (1-870): 0: 982: 100.00		UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57
+	Hs
		125225 WWP2_HUMAN (1-870): 0: 982: 100.00		BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22
+	Hs
		125112 WWP2_HUMAN (1-870): 0: 982: 100.00		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		125347 WWP2_HUMAN (1-870): 0: 982: 100.00		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47
+	Hs
		475140 ITCH_HUMAN (1-870): 0: 902: 54.26		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47
+	Hs
		872180 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00
+	Sp
		145418 PUB3_SCHPO (13-870): 0: 714: 32.69		RL402_SCHPO (3-129): 2.29e-37: 132: 21.26
+	Hs
		474953 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Hs
		803611 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22
+	Hs
		924336 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RL40_HUMAN (3-129): 1.37e-38: 136: 22.84
+	Hs
		475080 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (3-93): 2.96e-16: 77.1: 27.47
+	Dm
		89880 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		RL40_DROME (3-129): 2.8e-38: 134: 22.84
+	Sc
		477647 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RL40A_YEAST (3-129): 1.25e-32: 120: 20.47
+	Hs
		872218 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00
+	Hs
		1336119 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47
+	Hs
		1336106 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08