HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 409
+	Hs
		125281 WWP2_HUMAN (1-870): 0: 982: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		125787 WWP2_HUMAN (1-870): 0: 982: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Hs
		125739 WWP2_HUMAN (1-870): 0: 982: 100.00		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Hs
		125112 WWP2_HUMAN (1-870): 0: 982: 100.00		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Hs
		125347 WWP2_HUMAN (1-870): 0: 982: 100.00		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67
+	Hs
		475140 ITCH_HUMAN (1-870): 0: 902: 54.26		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67
+	Hs
		872180 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		474953 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Sp
		145418 PUB3_SCHPO (13-870): 0: 714: 32.69		RL402_SCHPO (1-84): 4.44e-14: 70.4: 28.57
+	Mm
		476858 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		475080 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	Hs
		924336 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RL40_HUMAN (1-91): 3.57e-33: 122: 28.57
+	At
		1091758 UPL1_ARATH (359-868): 4.41e-172: 555: 33.40		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	At
		1091762 UPL2_ARATH (374-868): 2.79e-170: 550: 33.91		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (1-90): 2.44e-15: 75: 26.67
+	Dm
		89880 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		RL40_DROME (1-84): 1.42e-15: 74.6: 29.76
+	Sc
		477647 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RL40A_YEAST (1-84): 4.44e-14: 70.4: 28.57
+	Hs
		872218 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		1336106 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68