HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25071155, 31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 406
+	Hs
		125142 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Hs
		125617 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX17_HUMAN (2-406): 1.31e-136: 409: 29.33
+	Hs
		125203 WWP2_HUMAN (1-870): 0: 982: 100.00		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		757756 WWP1_HUMAN (1-870): 0: 888: 58.38		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		125164 WWP2_HUMAN (1-870): 0: 982: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Sc
		485815 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		IF4A_YEAST (20-406): 8.01e-168: 477: 66.41
+	Hs
		757666 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		892840 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Sc
		624167 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		DBP2_YEAST (2-404): 8.49e-137: 403: 31.63
+	Hs
		571603 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88
+	Sc
		761942 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		DHH1_YEAST (32-402): 1.41e-99: 307: 44.47