HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: RS27A (P62979)
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Gene: RPS27A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0016567 - protein ubiquitination and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 156
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		125112 WWP2_HUMAN (1-870): 0: 982: 100.00		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Hs
		475140 ITCH_HUMAN (1-870): 0: 902: 54.26		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Rn
		1140970 Q5YB86_RAT (11-870): 0: 876: 55.68		UBC_RAT (1-119): 1.57e-36: 134: 68.29
+	Sp
		145416 PUB3_SCHPO (13-870): 0: 714: 32.69		RS27A_SCHPO (1-151): 1.04e-57: 178: 81.46
+	Sp
		145417 PUB3_SCHPO (13-870): 0: 714: 32.69		RS27B_SCHPO (1-151): 8.29e-58: 178: 81.46
+	Hs
		474953 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Sp
		145418 PUB3_SCHPO (13-870): 0: 714: 32.69		RL402_SCHPO (1-125): 7.03e-41: 135: 63.20
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (1-156): 8.08e-76: 224: 99.36
+	Hs
		924336 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Mm
		476858 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		UBC_MOUSE (1-119): 1.07e-36: 135: 67.48
+	Sc
		408448 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RS31_YEAST (1-151): 4.55e-61: 187: 82.78
+	Hs
		475080 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	At
		1091758 UPL1_ARATH (359-868): 4.41e-172: 555: 33.40		UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81
+	At
		1091762 UPL2_ARATH (374-868): 2.79e-170: 550: 33.91		UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81
+	Dm
		89880 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		RL40_DROME (1-125): 1.01e-43: 142: 64.80
+	Sc
		477647 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RL40A_YEAST (1-125): 2.07e-42: 139: 64.00
+	Dm
		1376481 Q9W325_DROME (451-870): 1.26e-172: 508: 44.37		Q9W418_DROME (1-77): 1.7e-34: 127: 100.00
+	Hs
		924414 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		475196 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00