HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	16189514, 31048545
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 656
+	Hs
		125616 WWP2_HUMAN (1-870): 0: 982: 100.00		RBP56_HUMAN (109-555): 5.78e-53: 193: 35.05
+	Hs
		967360 ITCH_HUMAN (1-870): 0: 902: 54.26		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Hs
		967423 WWP1_HUMAN (1-870): 0: 888: 58.38		EWS_HUMAN (1-656): 1.54e-47: 179: 100.00
+	Sc
		633986 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		GBP2_YEAST (343-453): 3.82e-16: 83.2: 24.56