HitPredict

Interactor 1: TRPM4 (Q8TD43)
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
Gene: TRPM4

Interactor 2: S10AE (Q9HCY8)
Protein S100-A14 (S100 calcium-binding protein A14) (S114)
Gene: S100A14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1214 Hs			1 104
+	Hs
		615221 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A1_HUMAN (16-95): 1.03e-27: 98.4: 26.19
+	Hs
		639026 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S100P_HUMAN (15-96): 4.1e-27: 96.9: 23.26
+	Hs
		685179 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10AB_HUMAN (16-96): 1.36e-26: 96.1: 27.06
+	Hs
		416480 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A9_HUMAN (14-104): 5.38e-26: 94.5: 30.00
+	Hs
		893818 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10AA_HUMAN (16-95): 4.45e-26: 94.5: 28.92
+	Hs
		642972 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A4_HUMAN (17-97): 2.93e-24: 89.9: 27.06
+	Hs
		380818 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S100B_HUMAN (15-97): 6.66e-24: 88.8: 27.59
+	Hs
		661361 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A2_HUMAN (16-95): 3.18e-23: 87.2: 25.00
+	Hs
		396768 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A8_HUMAN (15-98): 5.64e-23: 86.5: 21.59
+	Hs
		707352 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A5_HUMAN (16-94): 7.23e-22: 83.4: 23.75
+	Hs
		416665 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A6_HUMAN (17-92): 1e-21: 83: 26.92
+	Hs
		707382 TRPM4_HUMAN (1-1214): 0: 1243: 100.00		S10A3_HUMAN (17-97): 6.22e-21: 81.4: 18.82