HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: SCN5A (Q14524)
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
Gene: SCN5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15548568
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 2016
+	Hs
		1055040 NED4L_HUMAN (5-867): 0: 785: 32.17		SCN5A_HUMAN (1-2016): 0: 2020: 100.00
+	Hs
		808128 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN5A_HUMAN (1-2016): 0: 2020: 100.00
+	Mm
		93283 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN5A_MOUSE (1-2016): 0: 2002: 94.35
+	Hs
		723839 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN1A_HUMAN (3-2000): 0: 1819: 60.28
+	Mm
		69865 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN2A_MOUSE (3-2000): 0: 1857: 61.30
+	Mm
		93274 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN9A_MOUSE (2-2000): 0: 1831: 59.82
+	Mm
		93276 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNAA_MOUSE (5-2003): 0: 1830: 60.31
+	Hs
		808340 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNAA_HUMAN (5-2004): 0: 1774: 61.55
+	Hs
		808322 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN8A_HUMAN (2-2000): 0: 1730: 59.39
+	Mm
		93284 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN8A_MOUSE (2-2000): 0: 1737: 59.92
+	Mm
		808378 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN5A_MOUSE (1-2016): 0: 2002: 94.35
+	Mm
		69867 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN2A_MOUSE (3-2000): 0: 1857: 61.30
+	Mm
		808358 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN9A_MOUSE (2-2000): 0: 1831: 59.82
+	Mm
		808363 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCNAA_MOUSE (5-2003): 0: 1830: 60.31
+	Hs
		723851 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SCN1A_HUMAN (3-2000): 0: 1819: 60.28
+	Mm
		808381 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN8A_MOUSE (2-2000): 0: 1737: 59.92
+	Hs
		125445 WWP2_HUMAN (1-870): 0: 982: 100.00		CAC1C_HUMAN (355-555): 8.77e-10: 66.4: 14.09
+	Mm
		93270 E9PXB7_MOUSE (151-867): 0: 684: 37.10		Q3UF73_MOUSE (4-204): 1.61e-85: 280: 67.16
+	Hs
		1047217 NED4L_HUMAN (5-867): 0: 785: 32.17		CAC1C_HUMAN (355-555): 8.77e-10: 66.4: 14.09
+	Mm
		808349 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		Q3UF73_MOUSE (4-204): 1.61e-85: 280: 67.16