HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	28514442, 31048545, 33961781, 16189514, 35271311
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 551
+	Hs
		1084573 ITCH_HUMAN (1-870): 0: 902: 54.26		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084614 WWP1_HUMAN (1-870): 0: 888: 58.38		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		125259 WWP2_HUMAN (1-870): 0: 982: 100.00		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		125581 WWP2_HUMAN (1-870): 0: 982: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125260 WWP2_HUMAN (1-870): 0: 982: 100.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		125430 WWP2_HUMAN (1-870): 0: 982: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		125122 WWP2_HUMAN (1-870): 0: 982: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1235773 ITCH_HUMAN (1-870): 0: 902: 54.26		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		1235798 WWP1_HUMAN (1-870): 0: 888: 58.38		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125274 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		125061 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Hs
		125687 WWP2_HUMAN (1-870): 0: 982: 100.00		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		125698 WWP2_HUMAN (1-870): 0: 982: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Mm
		1208066 WWP2_MOUSE (1-870): 0: 971: 95.98		DIDO1_MOUSE (151-446): 1.18e-09: 63.3: 17.16
+	Hs
		808144 NEDD4_HUMAN (90-867): 0: 731: 35.94		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		516643 ITCH_HUMAN (1-870): 0: 902: 54.26		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1311993 WWP1_HUMAN (1-870): 0: 888: 58.38		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Sc
		376913 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		1084629 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		846873 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93