HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: AMOT (Q4VCS5)
Angiomotin
Gene: AMOT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	26186194, 25071155, 28514442, 31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1084
+	Hs
		1119026 ITCH_HUMAN (1-870): 0: 902: 54.26		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		1119052 WWP1_HUMAN (1-870): 0: 888: 58.38		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		125569 WWP2_HUMAN (1-870): 0: 982: 100.00		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		1119034 NED4L_HUMAN (5-867): 0: 785: 32.17		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		125260 WWP2_HUMAN (1-870): 0: 982: 100.00		SMCA4_HUMAN (46-592): 7.62e-32: 137: 12.59
+	Hs
		125805 WWP2_HUMAN (1-870): 0: 982: 100.00		AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81
+	Hs
		808151 NEDD4_HUMAN (90-867): 0: 731: 35.94		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		125768 WWP2_HUMAN (1-870): 0: 982: 100.00		RRBP1_HUMAN (179-773): 3.57e-12: 73: 12.40
+	Hs
		1222267 WWP1_HUMAN (1-870): 0: 888: 58.38		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		125451 WWP2_HUMAN (1-870): 0: 982: 100.00		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		1327936 WWP1_HUMAN (1-870): 0: 888: 58.38		AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81
+	Hs
		1078893 ITCH_HUMAN (1-870): 0: 902: 54.26		ITSN1_HUMAN (554-1077): 1.63e-09: 64.6: 9.32
+	Hs
		1327928 WWP1_HUMAN (1-870): 0: 888: 58.38		RRBP1_HUMAN (179-773): 3.57e-12: 73: 12.40
+	Hs
		1222263 NED4L_HUMAN (5-867): 0: 785: 32.17		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		808183 NEDD4_HUMAN (90-867): 0: 731: 35.94		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		808328 NEDD4_HUMAN (90-867): 0: 731: 35.94		AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81
+	Hs
		724896 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		1119083 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		1051472 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		149380 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		CTRO_HUMAN (533-815): 3.66e-12: 73.4: 12.37