HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBAP2 (Q5T6F2)
Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2)
Gene: UBAP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31048545, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 1119
+	Hs
		1134134 ITCH_HUMAN (1-870): 0: 902: 54.26		UBAP2_HUMAN (1-1119): 5.13e-116: 388: 100.00
+	Hs
		125449 WWP2_HUMAN (1-870): 0: 982: 100.00		UBP2L_HUMAN (1-1119): 1.83e-54: 209: 39.07
+	Hs
		1049868 ITCH_HUMAN (1-870): 0: 902: 54.26		UBP2L_HUMAN (1-1119): 1.83e-54: 209: 39.07
+	Hs
		125040 WWP2_HUMAN (1-870): 0: 982: 100.00		ANR17_HUMAN (423-1113): 1.88e-12: 74.1: 12.71
+	Hs
		125061 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24D_HUMAN (339-539): 3.93e-11: 69.5: 17.84
+	Hs
		125274 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24C_HUMAN (315-673): 4.4e-10: 66.4: 13.01
+	Hs
		554367 WWP1_HUMAN (1-870): 0: 888: 58.38		MUC1_HUMAN (338-1112): 2.49e-15: 83.3: 12.52
+	Hs
		808125 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBP2L_HUMAN (1-1119): 1.83e-54: 209: 39.07
+	Dm
		1370333 Q9VXR3_DROME (246-868): 6.38e-161: 523: 27.52		Q9VLS7_DROME (185-1113): 1.35e-21: 104: 9.45
+	Hs
		1170093 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		SRCAP_HUMAN (154-1116): 5.26e-24: 112: 10.80