HitPredict

Interactor 1: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_2, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0098609 - cell-cell adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1919 Hs			1 1190
+	Hs
		990892 DLG5_HUMAN (1-1919): 0: 936: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		159249 DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Rn
		1144009 DLG1_RAT (1120-1916): 6.2e-163: 524: 21.03		CSKP_RAT (229-890): 1.15e-93: 323: 15.72
+	Mm
		251104 DLG1_MOUSE (1120-1916): 1.24e-161: 521: 21.13		CSKP_MOUSE (229-890): 6.48e-93: 321: 15.09
+	Mm
		936180 DLG3_MOUSE (1133-1916): 0: 576: 19.56		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Rn
		677790 DLG3_RAT (1133-1916): 0: 573: 19.56		DLG4_RAT (3-423): 1.74e-52: 199: 18.89
+	Mm
		1119795 Q52KF7_MOUSE (1133-1916): 1.19e-177: 561: 19.09		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		942364 DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		936188 DLG3_MOUSE (1133-1916): 0: 576: 19.56		DLG2_MOUSE (8-534): 5.21e-45: 178: 15.58
+	Rn
		1144010 DLG3_RAT (1133-1916): 0: 573: 19.56		DLG1_RAT (1-513): 8.04e-44: 174: 16.64
+	Hs
		1021542 DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97		DLG1_HUMAN (1-515): 2.7e-47: 185: 16.38
+	Hs
		1077285 DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97		DLG2_HUMAN (8-518): 4.46e-45: 178: 15.49
+	Rn
		677787 DLG1_RAT (1120-1916): 6.2e-163: 524: 21.03		DLG4_RAT (3-423): 1.74e-52: 199: 18.89
+	Mm
		1143387 DLG1_MOUSE (1120-1916): 1.24e-161: 521: 21.13		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143467 DLG2_MOUSE (1165-1916): 1.68e-159: 513: 19.18		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1113136 Q3UP61_MOUSE (1120-1916): 7.07e-157: 507: 21.56		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Rn
		1144014 DLG1_RAT (1120-1916): 6.2e-163: 524: 21.03		DLG2_RAT (8-534): 1.37e-45: 179: 15.41