HitPredict

Interactor 1: BRX1 (Q8TDN6)
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)
Gene: BRIX1

Interactor 2: MK67I (Q9BYG3)
MKI67 FHA domain-interacting nucleolar phosphoprotein (Nucleolar phosphoprotein Nopp34) (Nucleolar protein interacting with the FHA domain of pKI-67) (hNIFK)
Gene: NIFK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005694 - chromosome GO:0005730 - nucleolus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 293
+	Sc
		866278 BRX1_YEAST (40-305): 1.92e-92: 279: 45.32		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64
+	Hs
		1316887 RPF1_HUMAN (13-269): 1.37e-72: 230: 20.83		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Sc
		866245 IMP4_YEAST (4-278): 4.96e-80: 248: 18.51		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64
+	Sc
		755312 RPF1_YEAST (4-269): 5.6e-62: 201: 15.33		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64
+	Hs
		1316881 RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Hs
		1316896 SSF1_HUMAN (54-228): 2.87e-21: 96.4: 15.22		MK67I_HUMAN (1-293): 8.07e-53: 176: 100.00
+	Sc
		754891 SSF1_YEAST (39-230): 7.36e-18: 86.4: 14.88		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64
+	Sc
		866287 SSF2_YEAST (39-230): 1.83e-17: 84.9: 14.42		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64
+	Sc
		733890 RPF2_YEAST (71-267): 1.62e-13: 72.5: 19.56		NOP15_YEAST (14-185): 3.16e-37: 133: 30.64