HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: TM1L2 (Q6ZVM7)
TOM1-like protein 2 (Target of Myb-like protein 2)
Gene: TOM1L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 507
+	Hs
		125035 WWP2_HUMAN (1-870): 0: 982: 100.00		TOM1_HUMAN (1-507): 1.07e-155: 454: 61.40
+	Hs
		125613 WWP2_HUMAN (1-870): 0: 982: 100.00		STAM1_HUMAN (1-491): 2.46e-92: 293: 19.80
+	Hs
		808171 NEDD4_HUMAN (90-867): 0: 731: 35.94		TM1L2_HUMAN (1-507): 1.43e-180: 518: 100.00
+	Hs
		1270607 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM1_HUMAN (1-491): 2.46e-92: 293: 19.80
+	Hs
		1294876 ITCH_HUMAN (1-870): 0: 902: 54.26		GGA3_HUMAN (12-497): 1.56e-90: 293: 20.36
+	Hs
		241153 NEDD4_HUMAN (90-867): 0: 731: 35.94		TOM1_HUMAN (1-507): 1.07e-155: 454: 61.40
+	Hs
		277114 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM2_HUMAN (1-501): 1.54e-83: 269: 17.97
+	Hs
		125001 WWP2_HUMAN (1-870): 0: 982: 100.00		HGS_HUMAN (13-166): 1.32e-41: 160: 33.55
+	Hs
		160143 ITCH_HUMAN (1-870): 0: 902: 54.26		HGS_HUMAN (13-166): 1.32e-41: 160: 33.55
+	Hs
		808298 NEDD4_HUMAN (90-867): 0: 731: 35.94		GGA3_HUMAN (12-497): 1.56e-90: 293: 20.36
+	Hs
		160160 NED4L_HUMAN (5-867): 0: 785: 32.17		HGS_HUMAN (13-166): 1.32e-41: 160: 33.55
+	Hs
		159925 NEDD4_HUMAN (90-867): 0: 731: 35.94		HGS_HUMAN (13-166): 1.32e-41: 160: 33.55
+	Hs
		1173029 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TM1L2_HUMAN (1-507): 1.43e-180: 518: 100.00
+	Hs
		241199 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TOM1_HUMAN (1-507): 1.07e-155: 454: 61.40