HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 712
+	Hs
		125260 WWP2_HUMAN (1-870): 0: 982: 100.00		SMCA4_HUMAN (153-599): 1.86e-39: 159: 11.43
+	Hs
		125259 WWP2_HUMAN (1-870): 0: 982: 100.00		SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59
+	Hs
		125274 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24C_HUMAN (210-493): 5.8e-12: 71.3: 13.44
+	Hs
		123777 WWP2_HUMAN (1-870): 0: 982: 100.00		SPT5H_HUMAN (58-209): 8.32e-09: 61.3: 13.64
+	Hs
		554367 WWP1_HUMAN (1-870): 0: 888: 58.38		MUC1_HUMAN (54-680): 4.91e-23: 107: 9.24
+	Dm
		1370333 Q9VXR3_DROME (246-868): 6.38e-161: 523: 27.52		Q9VLS7_DROME (55-541): 2.19e-09: 63.3: 9.25
+	Sc
		758550 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		SEC31_YEAST (69-353): 7.19e-09: 61.3: 12.80
+	Hs
		846873 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SMCA2_HUMAN (176-599): 1.02e-36: 150: 13.59
+	Hs
		1264807 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		TITIN_HUMAN (134-417): 2.57e-09: 63.2: 9.72
+	Hs
		1295414 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		CHAP1_HUMAN (63-511): 1.2e-19: 96: 13.16