HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: Q8WU02 (Q8WU02)
C9orf61 protein
Gene: Q8WU02

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 176
+	Hs
		125488 WWP2_HUMAN (1-870): 0: 982: 100.00		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		1259694 WWP1_HUMAN (1-870): 0: 888: 58.38		Q8WU02_HUMAN (1-176): 3.8e-108: 307: 100.00
+	Hs
		1079771 ITCH_HUMAN (1-870): 0: 902: 54.26		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		1079783 WWP1_HUMAN (1-870): 0: 888: 58.38		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		1079773 NED4L_HUMAN (5-867): 0: 785: 32.17		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		808136 NEDD4_HUMAN (90-867): 0: 731: 35.94		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		1079753 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00
+	Hs
		1079795 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		EREP1_HUMAN (1-124): 3.97e-88: 266: 100.00