HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	26490116, 37010382
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 868
+	Hs
		1260379 ITCH_HUMAN (1-870): 0: 902: 54.26		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		1260380 NED4L_HUMAN (5-867): 0: 785: 32.17		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Hs
		808202 NEDD4_HUMAN (90-867): 0: 731: 35.94		PDC6I_HUMAN (1-868): 0: 677: 100.00
+	Dm
		1374363 SUDX_DROME (14-870): 0: 852: 52.14		Q9VUH6_DROME (4-865): 5.54e-107: 365: 21.32
+	Hs
		125692 WWP2_HUMAN (1-870): 0: 982: 100.00		KIFC1_HUMAN (433-828): 2.3e-37: 151: 13.85
+	Hs
		60531 WWP2_HUMAN (1-870): 0: 982: 100.00		VP37C_HUMAN (540-856): 2.14e-25: 110: 18.81
+	Hs
		123777 WWP2_HUMAN (1-870): 0: 982: 100.00		SPT5H_HUMAN (703-829): 2.18e-10: 66.9: 19.42
+	Hs
		808106 NEDD4_HUMAN (90-867): 0: 731: 35.94		EP300_HUMAN (527-867): 6.39e-32: 136: 13.70
+	Hs
		724896 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01
+	Sc
		765321 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		BRO1_YEAST (1-804): 8.13e-106: 348: 21.37