HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: WBP2 (Q969T9)
WW domain-binding protein 2 (WBP-2)
Gene: WBP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	25071155, 31048545, 31578285, 33961781, 27578003, 9169421, 35331737
Identification Methods	affinity chromatography technology, pull down, two hybrid, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 261
+	Hs
		1282371 ITCH_HUMAN (1-870): 0: 902: 54.26		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1282381 WWP1_HUMAN (1-870): 0: 888: 58.38		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1282372 NED4L_HUMAN (5-867): 0: 785: 32.17		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		808210 NEDD4_HUMAN (90-867): 0: 731: 35.94		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Hs
		1192157 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00
+	Mm
		808347 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		WBP2_MOUSE (1-261): 1.95e-70: 218: 96.94
+	Ce
		1090426 WWP1_CAEEL (6-366): 1.19e-31: 134: 19.44		Q18966_CAEEL (1-231): 7.38e-52: 170: 32.64