HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35331737
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 577
+	Hs
		125451 WWP2_HUMAN (1-870): 0: 982: 100.00		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		1287337 ITCH_HUMAN (1-870): 0: 902: 54.26		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		125464 WWP2_HUMAN (1-870): 0: 982: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		1294893 ITCH_HUMAN (1-870): 0: 902: 54.26		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1327944 WWP1_HUMAN (1-870): 0: 888: 58.38		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1078893 ITCH_HUMAN (1-870): 0: 902: 54.26		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		1113845 WWP1_HUMAN (1-870): 0: 888: 58.38		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		1223642 HACE1_HUMAN (374-864): 5.08e-160: 492: 31.05		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Mm
		1112154 HACE1_MOUSE (374-864): 1.82e-163: 501: 31.62		OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80
+	Hs
		1192196 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		CP250_HUMAN (15-545): 9.03e-15: 80.3: 11.07
+	Hs
		724896 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Hs
		1051472 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		551845 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60
+	Hs
		1061257 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		1113852 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		502881 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64
+	Hs
		149380 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59