HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31048545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043433 - negative regulation of DNA-binding transcription factor activity GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 299
+	Hs
		125187 WWP2_HUMAN (1-870): 0: 982: 100.00		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		1305252 WWP1_HUMAN (1-870): 0: 888: 58.38		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		719065 ITCH_HUMAN (1-870): 0: 902: 54.26		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Hs
		1192182 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		PHB2_HUMAN (1-299): 2.46e-109: 320: 100.00
+	Hs
		718957 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		PHB1_HUMAN (22-280): 1e-85: 259: 51.15
+	Sc
		837189 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		PHB2_YEAST (3-281): 1.83e-80: 247: 53.21