HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: LITAF (Q99732)
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Gene: LITAF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	25963657, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 161
+	Hs
		1294843 ITCH_HUMAN (1-870): 0: 902: 54.26		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		1306061 WWP1_HUMAN (1-870): 0: 888: 58.38		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		1299608 NED4L_HUMAN (5-867): 0: 785: 32.17		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808241 NEDD4_HUMAN (90-867): 0: 731: 35.94		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808268 NEDD4_HUMAN (90-867): 0: 731: 35.94		CDIP1_HUMAN (72-161): 2.31e-23: 93: 36.67
+	Mm
		808379 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		LITAF_MOUSE (1-161): 7.43e-50: 159: 85.71
+	Hs
		1306072 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Ce
		1276020 WWP1_CAEEL (6-366): 1.19e-31: 134: 19.44		Q94184_CAEEL (67-161): 9.08e-21: 84.9: 33.68