Interactor 1: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6
Interactor 2: RPGF2 (Q9Y4G8)
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
Gene: RAPGEF2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 1.00 | 0.665 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33961781 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | RasGEF_N~cNMP_binding, PDZ~PDZ, RA~RA, RasGEF~RasGEF, RasGEF~RasGEF_N |
| Common GO terms | GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0016324 - apical plasma membrane and 5 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
