HitPredict

Interactor 1: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Interactor 2: EXOS8 (Q96B26)
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)
Gene: EXOSC8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.952

Property	Details
Experiments	26186194, 28514442, 26496610, 24981860, 33961781, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, OB_Dis3~RNase_PH_C, RNB~RNase_PH
Common GO terms	GO:0000177 - cytoplasmic exosome (RNase complex) GO:0005829 - cytosol GO:0006396 - RNA processing GO:0006401 - RNA catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1054 Hs			1 276
+	Hs
		1063744 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS7_HUMAN (1-275): 7.22e-77: 237: 25.36
+	Hs
		986702 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS9_HUMAN (1-275): 2.37e-68: 220: 27.08
+	Hs
		1257153 DI3L1_HUMAN (1-1054): 0: 1322: 100.00		EXOS4_HUMAN (14-276): 2.33e-53: 175: 18.35
+	Hs
		1284999 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS8_HUMAN (1-276): 8.37e-92: 274: 100.00
+	Hs
		1063785 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS7_HUMAN (1-275): 7.22e-77: 237: 25.36
+	Hs
		986739 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS9_HUMAN (1-275): 2.37e-68: 220: 27.08
+	Hs
		1342631 RRP44_HUMAN (5-991): 0: 1027: 33.76		EXOS4_HUMAN (14-276): 2.33e-53: 175: 18.35
+	Dm
		1250326 Q9VC93_DROME (7-988): 0: 943: 31.52		Q8T4A9_DROME (3-275): 1.55e-72: 229: 23.64
+	Sp
		252320 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP45_SCHPO (7-276): 5.68e-73: 226: 28.68
+	Dm
		1100453 Q9VC93_DROME (7-988): 0: 943: 31.52		Q29QQ9_DROME (1-276): 1.97e-68: 215: 25.00
+	Sp
		740351 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP43_SCHPO (2-258): 3.44e-69: 216: 38.91
+	Dm
		1362696 Q9VC93_DROME (7-988): 0: 943: 31.52		Q9VK19_DROME (16-273): 8.9e-54: 176: 14.29
+	At
		96521 F4INI6_ARATH (1-972): 0: 934: 31.24		RRP41_ARATH (20-276): 2.61e-56: 182: 19.16
+	Sp
		194782 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP41_SCHPO (12-275): 2.12e-49: 164: 16.85
+	Sc
		984317 RRP44_YEAST (2-971): 0: 893: 31.47		RRP45_YEAST (7-276): 3.46e-67: 212: 26.32
+	Sp
		223963 DIS3_SCHPO (5-972): 0: 941: 32.54		RRP42_SCHPO (6-270): 1.8e-34: 127: 19.73
+	Sc
		809596 RRP44_YEAST (2-971): 0: 893: 31.47		RRP41_YEAST (20-276): 8.36e-40: 140: 19.08
+	Sc
		993688 RRP44_YEAST (2-971): 0: 893: 31.47		RRP42_YEAST (6-234): 8.46e-35: 127: 17.30
+	Pf
		1212338 Q8IDB6_PLAF7 (6-301): 2.09e-67: 248: 16.57		Q8ID62_PLAF7 (9-274): 2.12e-66: 215: 25.00