HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBQL4 (Q9NRR5)
Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
Gene: UBQLN4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 601
+	Hs
		125787 WWP2_HUMAN (1-870): 0: 982: 100.00		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Hs
		125225 WWP2_HUMAN (1-870): 0: 982: 100.00		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		125281 WWP2_HUMAN (1-870): 0: 982: 100.00		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		125282 WWP2_HUMAN (1-870): 0: 982: 100.00		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Hs
		125347 WWP2_HUMAN (1-870): 0: 982: 100.00		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55
+	Sp
		145418 PUB3_SCHPO (13-870): 0: 714: 32.69		RL402_SCHPO (13-105): 2.86e-29: 114: 27.66
+	Hs
		803611 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		BAG6_HUMAN (2-547): 7.28e-64: 229: 13.41
+	Hs
		872180 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		924336 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26
+	At
		1091758 UPL1_ARATH (359-868): 4.41e-172: 555: 33.40		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	At
		1091762 UPL2_ARATH (374-868): 2.79e-170: 550: 33.91		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (13-99): 1.13e-12: 68.1: 29.55
+	Sc
		477647 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		RL40A_YEAST (13-105): 7.04e-30: 115: 28.72
+	Dm
		89880 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		RL40_DROME (13-104): 2.35e-29: 114: 27.96
+	Hs
		1336119 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Hs
		1336106 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Hs
		872218 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		924414 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26