Interactor 1: FBXW7 (Q8VBV4)
F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10)
Gene: FBXW7

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 25670854, 29472293, 11735228
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~F-box-like
Common GO terms GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0030674 - protein-macromolecule adaptor activity
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031625 - ubiquitin protein ligase binding
and 1 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 710
Mm

1 776
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Hs
+ Sc
+ Sp
+ Hs
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024