HitPredict

Interactor 1: Q8VD35 (Q8VD35)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Interactor 2: DMBX1 (Q91ZK4)
Diencephalon/mesencephalon homeobox protein 1 (Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein) (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1) (Paired-type homeobox Atx)
Gene: DMBX1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15890343
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 289 Mm			1 381
+	Mm
		945791 OTX2_MOUSE (1-289): 6.1e-75: 232: 99.65		DMBX1_MOUSE (1-381): 7.28e-68: 220: 100.00
+	Hs
		686545 OTX2_HUMAN (1-289): 1.73e-75: 234: 99.31		OTX2_HUMAN (36-281): 7.02e-36: 134: 24.81
+	Mm
		222324 Q8VD35_MOUSE (1-289): 1.77e-74: 231: 100.00		CRX_MOUSE (39-263): 1.2e-36: 136: 30.00
+	Mm
		945790 OTX2_MOUSE (1-289): 6.1e-75: 232: 99.65		OTX2_MOUSE (36-281): 1.22e-35: 133: 25.19
+	Mm
		1265275 DMBX1_MOUSE (31-160): 4.51e-38: 140: 41.22		DMBX1_MOUSE (1-381): 7.28e-68: 220: 100.00
+	Hs
		686548 OTX2_HUMAN (1-289): 1.73e-75: 234: 99.31		LHX1_HUMAN (9-274): 1.31e-30: 122: 18.51
+	Mm
		192304 Q8VD35_MOUSE (1-289): 1.77e-74: 231: 100.00		ALX4_MOUSE (10-238): 3.26e-31: 124: 26.64
+	Mm
		192303 Q8R0B5_MOUSE (1-289): 4.77e-71: 222: 96.63		ALX4_MOUSE (10-238): 3.26e-31: 124: 26.64
+	Mm
		926108 PAX6_MOUSE (5-250): 1.42e-34: 131: 24.39		VSX2_MOUSE (76-220): 7.08e-49: 170: 33.56
+	Hs
		641359 PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39		VSX2_HUMAN (76-220): 9.26e-48: 167: 33.56
+	Hs
		197795 RAX2_HUMAN (19-161): 6.91e-40: 139: 34.00		CRX_HUMAN (39-264): 1.57e-37: 139: 32.31
+	Bt
		1187205 RAX2_BOVIN (35-162): 1.5e-39: 138: 35.56		CRX_BOVIN (39-264): 9.34e-38: 139: 30.97
+	Mm
		192281 PAX3_MOUSE (12-275): 1.39e-35: 135: 25.09		ALX4_MOUSE (10-238): 3.26e-31: 124: 26.64
+	Hs
		1077278 ALX1_HUMAN (2-197): 2.59e-37: 136: 28.14		ALX4_HUMAN (10-238): 1.37e-30: 122: 27.07
+	Mm
		936459 PITX1_MOUSE (14-259): 5.43e-35: 130: 27.02		PITX1_MOUSE (5-301): 1.57e-32: 125: 24.58
+	Hs
		1255791 LHX3_HUMAN (39-264): 6.99e-35: 131: 21.46		LMX1A_HUMAN (22-263): 1.57e-30: 122: 18.62
+	Hs
		822689 LHX3_HUMAN (39-264): 6.99e-35: 131: 21.46		LHX1_HUMAN (9-274): 1.31e-30: 122: 18.51
+	Hs
		641325 PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39		PAX6_HUMAN (69-131): 3.44e-17: 84.3: 63.49