HitPredict

Interactor 1: Q8VD35 (Q8VD35)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Interactor 2: MIXL1 (Q9WUI0)
Homeobox protein MIXL1 (Homeodomain protein MIX) (mMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein)
Gene: MIXL1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	20211142
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 289 Mm			1 231
+	Mm
		1246769 Q8R0B5_MOUSE (1-289): 4.77e-71: 222: 96.63		MIXL1_MOUSE (1-231): 2.4e-48: 160: 100.00
+	Mm
		192304 Q8VD35_MOUSE (1-289): 1.77e-74: 231: 100.00		ALX4_MOUSE (2-222): 2.76e-36: 133: 21.27
+	Hs
		686545 OTX2_HUMAN (1-289): 1.73e-75: 234: 99.31		OTX2_HUMAN (54-142): 6.04e-35: 127: 47.19
+	Mm
		945790 OTX2_MOUSE (1-289): 6.1e-75: 232: 99.65		OTX2_MOUSE (54-142): 7.08e-35: 127: 47.19
+	Hs
		686582 OTX2_HUMAN (1-289): 1.73e-75: 234: 99.31		NANOG_HUMAN (13-223): 1.02e-33: 124: 22.90
+	Mm
		192303 Q8R0B5_MOUSE (1-289): 4.77e-71: 222: 96.63		ALX4_MOUSE (2-222): 2.76e-36: 133: 21.27
+	Mm
		945791 OTX2_MOUSE (1-289): 6.1e-75: 232: 99.65		DMBX1_MOUSE (86-144): 1.47e-13: 70.9: 59.32
+	Mm
		1257445 Q8VD35_MOUSE (1-289): 1.77e-74: 231: 100.00		DMBX1_MOUSE (86-144): 1.47e-13: 70.9: 59.32
+	Mm
		222324 CRX_MOUSE (1-289): 8.79e-41: 145: 45.93		Q8VD35_MOUSE (54-142): 8.22e-35: 127: 47.19
+	Hs
		1077278 ALX1_HUMAN (2-197): 2.59e-37: 136: 28.14		ALX4_HUMAN (2-222): 5.85e-36: 132: 21.27
+	Mm
		192281 PAX3_MOUSE (12-275): 1.39e-35: 135: 25.09		ALX4_MOUSE (2-222): 2.76e-36: 133: 21.27
+	Hs
		641346 PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39		LHX2_HUMAN (24-228): 1.38e-36: 134: 23.42
+	Bt
		1187205 CRX_BOVIN (1-289): 2.1e-39: 141: 46.58		RAX2_BOVIN (83-198): 2.53e-33: 120: 39.34
+	Hs
		197795 CRX_HUMAN (1-289): 5.69e-41: 145: 46.91		RAX2_HUMAN (63-198): 1.02e-31: 116: 35.92
+	Hs
		641325 PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39		PAX6_HUMAN (25-231): 3.33e-33: 125: 23.67
+	Dm
		950110 Q9XZU0_DROME (30-281): 1.02e-37: 138: 23.93		UBX_DROME (29-150): 6.26e-30: 116: 22.13
+	Hs
		641609 PAX6_HUMAN (5-250): 1.42e-34: 131: 24.39		RX_HUMAN (22-216): 2.43e-31: 119: 22.82
+	Mm
		1265275 DMBX1_MOUSE (31-160): 4.51e-38: 140: 41.22		DMBX1_MOUSE (86-144): 1.47e-13: 70.9: 59.32